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猪虽易胖,但不易得代谢疾病---猪胆酸可以作为代谢紊乱的生物标志物

发布时间:2021-11-17   点击次数:823次

生活中我们会观察到,猪虽然易胖,但不易得代谢性疾病,对饮食诱导的糖尿病有极强的抵抗力。有趣的是,早在明代《本草纲目》中就有记载,猪胆主治消渴症(糖尿病症状)。上海交通大学附属第六人民医院 贾伟教授 贾伟平教授和香港浸会大学 吕爱平教授团队合作在 Nature Communications发表了题为Hyocholic acid species as novel biomarkers for metabolic disorder的研究论文, 揭示了猪胆酸在预测代谢紊乱相关疾病中发挥的重要作用

图片来源:Nature Communications

猪作为一种独特的哺乳动物,却对一些代谢疾病(T2DM,NAFLD 和 CVD) 具有异常的抵抗力。最近报道发现猪与人类的胆汁酸(BAs)有着明显的不同,猪体内有大量的猪胆酸(HCA)的存在(>75%)而人类体内只有仅仅 3% 左右。

胆汁酸的功能主要涉及肝脏内的胆固醇代谢,以及与肠道有关的胆固醇,脂溶性维他命和脂类的吸收。由于 BAs 在生理和代谢方面发挥着重要功能,研究人员探究人类体内 HCA 与代谢紊乱之间是否存在着未知的联系。

研究内容

 

肥胖症与糖尿病是与血液中低浓度 HCA 相关的

该团队对来自上海肥胖研究 (SHOS) 中的 1107 个样本(610 个男性和 497 个女性)进行分组:健康组(HL, n=585),健康肥胖组(HO,n=419)和肥胖糖尿病组(OD,n=103),随后进行了血清 BA 分析。结果发现 HO 和 OD 组相对于 HL 组,猪胆酸(HCA)与脱氧胆酸(DCA)水平显著降低。

随后,研究者对参与调查的人群进行年龄,体重,性别的调整,再次分析后发现 HO 与 OD 组相对 HL 组,HCA 仍旧保持低水平,但是 DCA 并没有上次的显著差异。与总体 HCA 水平相一致的是,单独的 HCA 种类(HCA,HDCA,GHCA 和 GHDCA)都表现出 HL 组中增高而 OD 组中降低的趋势。 这些结果表明了代谢紊乱包括肥胖和糖尿病都是与血清中低浓度的 HCA 相关的

图片来源:Nature Communications

前驱糖尿病和糖尿病与血液和排泄物中低浓度 HCA 有关

研究人员为了进一步证明上述结论,对糖尿病又进行了不同人群的验证。除了血清样本又添加了粪便样本,结果发现 非健康组的血清和粪便中总体 HCA 浓度降低

图片来源:Nature Communications

术前 HCA 浓度可能预测术后病情缓解效果

为了 进一步研究 HCA 水平改变的影响,研究人员对 38 个肥胖和糖尿病患者进行了胃分流术(RYGB),增加血清中总 BAs 的浓度,监测发现术后一个月血清中 HCA 水平显著升高。术后两年的随访调查发现,26 个病人病情仍旧保持缓解,而 12 个病人糖尿病复发。检测其体内 BAs 水平发现,总体 HCA 和大部分单独的 HCA 在缓解组中是显著高于复发组的。二元逻辑回归模型表明术前高浓度的 HCA 是与术后 2 年维持糖尿病缓解相关。

研究人员又将病人分为四组进行分析,发现术后 12 或 24 个月复发的病人术前 HCA 水平较低,而缓解的病人术前都有较高的 HCA 水平。因此, 术前 HCA 水平可能对于预测术后长期缓解有效

图片来源:Nature Communications

血清 HCA 是健康个体未来代谢结果的重要预测因子

为了进一步评估 HCA 与未来代谢健康的关系,该团队挑选了 132 个代谢健康的受试者(36 个男性和 96 个女性)。10 年后,86 个参与者代谢出现问题,而 46 人仍保持代谢健康。在健康组和非健康组中总 BAs 的浓度基本相同,但是总 HCA 和单独 HCA 种类在非健康组中显著较低。

二项逻辑回归分析所有的样本, 数据支持使用总 HCA 和单独 HCA 种类作为未来代谢结果的预测标志物。为了证实血清 HCA 对未来代谢结果的预测能力,该团队进一步收集了来自北京的 207 个血清样本,进行了独立的分析。结果验证了先前的结论, 总 HCA 与单独的 HCA 种类有着很强的预测能力

图片来源:Nature Communications

研究总结

本文发现了肥胖和糖尿病是与血清中低浓度的 HCA 有关,并且血清 HCA 水平与未来代谢健康的结果具有相关性。该团队 揭示了 HCA 种类与糖尿病之间的联系,以及 HCA 作为未来代谢异常发展的生物学标志物的可行性

本研究也存在不足之处,HCA 代谢外科手术的研究样本还需要进一步的扩大,并且 HCA 与二型糖尿病之间的具体机制有待进一步深入探究。

上海赛可锐生物可以提供胆酸产品,全面满足您的实验需求。


货号中文名英文名CAS
鼠胆酸系列


MTCH-10001α-鼠胆酸Alpha(α)-Muricholic Acid[2393-58-0]
MTCH-10002α-鼠胆酸-[d5]Alpha(α)-Muricholic Acid-[d5][2393-58-0  unlabelled]
MTCH-10003β-鼠胆酸Beta(β)-Muricholic Acid[2393-59-1]
MTCH-10004β-鼠胆酸-[d5]Beta(β)-Muricholic Acid-[d5][N/A]
MTCH-10005γ--鼠胆酸Gamma(γ)-Muricholic Acid[547-75-1]
MTCH-10006γ-鼠胆酸-[d5]Gamma(γ)-Muricholic Acid-[d5][N/A]
MTCH-10007ω-鼠胆酸Omega(ω)-Muricholic Acid[6830-03-1]
MTCH-10008ω-鼠胆酸-[d5]Omega(ω)-Muricholic Acid-[d5][N/A]
MTCH-10009牛磺-α-鼠胆酸钠盐Tauro-Alpha(α)-Muricholic Acid Sodium Salt[25613-05-2 (free base)]
MTCH-10010牛磺-α-鼠胆酸钠盐-[d4]Tauro-Alpha(α)-Muricholic Acid Sodium Salt-[d4][N/A]
MTCH-10011牛磺-β-鼠胆酸钠盐Tauro-Beta(β)-Muricholic Acid Sodium Salt[145022-92-0]
MTCH-10012牛磺-β-鼠胆酸钠盐-[d4]Tauro-Beta(β)-Muricholic Acid Sodium Salt-[d4][N/A]
MTCH-10013牛磺-ω-鼠胆酸钠盐Tauro-Omega(ω)-Muricholic Acid Sodium Salt[N/A]
MTCH-10014β-牛磺鼠胆酸葡萄糖醛酸钠盐Beta(β)-Tauromuricholic Acid Glucuronide Sodium Salt[dry ice][N/A]
MTCH-10015鼠脱氧胆酸Murideoxycholic Acid[668-49-5]
MTCH-10016甘氨酸-β-鼠胆酸Glycine-Beta(β)-Muricholic Acid[66225-78-3]
MTCH-10017贝塔-鼠胆酸3-乙酸甲酯Beta(β)-Muricholic Acid 3-Acetate Methyl Ester[N/A]
猪胆酸系列


MTCH-10021猪脱氧胆酸Hyodeoxycholic Acid[83-49-8]
MTCH-10022α-猪脱氧胆酸-[d5]Alpha(α)-Hyodeoxycholic Acid-[d5][83-49-8 unlabelled]
MTCH-10023β-猪脱氧胆酸-[d4]Beta(β)-Hyodeoxycholic Acid-[d4][83-49-8 unlabelled]
MTCH-10024α-猪脱氧胆酸甲酯Alpha(α)-Hyodeoxycholic Acid Methyl Ester[2868-48-6]
MTCH-10025β-猪脱氧胆酸甲酯-[d5]Beta(β)-Hyodeoxycholic Acid-[d5] Methyl Ester[N/A]
MTCH-10026甘氨猪脱氧胆酸Glycohyodeoxycholic Acid[13042-33-6]
MTCH-10027甘氨猪脱氧胆酸钠盐Glycohyodeoxycholic Acid Sodium Salt[N/A]
MTCH-10028甘氨猪脱氧胆酸-3-O-β-葡萄糖苷二钠盐Glycohyodeoxycholic Acid 3-O-Beta(β)-Glucuronide Disodium Salt[N/A]
MTCH-10029牛磺猪脱氧胆酸Taurohyodeoxycholic Acid[38411-85-7 (Na salt)]
MTCH-10030牛磺猪脱氧胆酸钠盐Taurohyodeoxycholic Acid Sodium Salt[110026-03-4]
MTCH-10031牛磺猪脱氧胆酸钠盐-[d4]Taurohyodeoxycholic Acid-[d4] Sodium Salt[N/A]
MTCH-10018猪胆酸甲酯Hyocholic Acid Methyl Ester[N/A]
MTCH-10019牛磺猪胆酸钠盐Taurohyocholic Acid, Sodium Salt[N/A]
MTCH-10020甘氨猪胆酸钠盐Glycohyocholic Acid, Sodium Salt[32747-08-3 (free acid)]
鹅脱氧胆酸系列


MTCH-10032鹅脱氧胆酸Chenodesoxycholic Acid[474-25-9]
MTCH-10033鹅脱氧胆酸甲酯Chenodeoxycholic Acid Methyl Ester[3057-04-3]
MTCH-10034鹅脱氧胆酸24-酰基-β-D-葡萄糖醛酸Chenodeoxycholic Acid 24-Acyl-Beta(β)-D-Glucuronide[208038-27-1]
MTCH-10035鹅脱氧胆酸-3-硫酸钠盐Chenodeoxycholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10036鹅脱氧胆酸-[d4]-3-硫酸钠盐Taurochenodeoxycholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-10037甲基鹅脱氧胆酸二乙酸酯Methylchenodeoxycholic Diacetate[2616-71-9]
货号中文名英文名CAS
MTCH-10038鹅脱氧胆酸-3-半琥珀酸Chenodeoxycholic Acid-3-Hemisuccinate[N/A]
MTCH-100391β-羟基鹅脱氧胆酸 1Beta(β)-Hydroxychenodeoxycholic Acid[N/A]
MTCH-10040牛磺鹅脱氧胆酸 Taurochenodeoxycholic Acid[516-35-8]
MTCH-10041牛磺鹅脱氧胆酸-[d4]钠盐 (溶液)Taurochenodeoxycholic Acid-[d4] Sodium Salt (Solution)[N/A]
MTCH-10042牛磺鹅脱氧胆酸-[d4]钠盐Taurochenodeoxycholic Acid-[d4] Sodium Salt[6009-98-9]
MTCH-10043牛磺鹅脱氧胆酸-[d5]钠盐Taurochenodeoxycholic Acid-[d5]Sodium Salt[N/A]
MTCH-10044牛磺鹅脱氧胆酸-[d9]钠盐 (溶液)Taurochenodeoxycholic Acid-[d9] Sodium Salt (Solution)[N/A]
MTCH-10045牛磺鹅脱氧胆酸-[d9]钠盐Taurochenodeoxycholic Acid-[d9] Sodium Salt[6009-98-9]
MTCH-10046牛磺鹅脱氧胆酸-3-O-葡糖苷酸Taurochenodeoxycholic Acid-3-O-Glucuronide[N/A]
MTCH-10047牛磺鹅脱氧胆酸-3-O-葡糖苷酸-[d4]Taurochenodeoxycholic Acid-3-O-Glucuronide-[d4] [dry ice][79252-49-6]
MTCH-10048牛磺鹅脱氧胆酸-3-硫酸钠盐Taurochenodeoxycholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10049牛磺鹅脱氧胆酸-[d4]-3-硫酸钠盐Taurochenodeoxycholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-10050异鹅脱氧胆酸Isochenodeoxycholic Acid[566-24-5]
MTCH-10051牛磺6-乙基鹅脱氧胆酸钠盐Tauro 6-Ethylchenodeoxycholic Acid Sodium Salt [N/A]
MTCH-10052牛磺6-乙基鹅脱氧胆酸钠盐-[d5]Tauro 6-Ethlchenodeoxycholic Acid-[d5] Sodium Salt[N/A]
MTCH-100531β-羟基牛磺鹅脱氧胆酸钠盐1Beta(β)-Hydroxytaurochenodeoxycholic Acid Sodium[N/A]
MTCH-100541β-羟基牛磺鹅脱氧胆酸1Beta(β)-Hydroxychenodeoxycholic Acid[N/A]
MTCH-10055甘氨鹅脱氧胆酸Glycochenodeoxycholic Acid[N/A]
MTCH-10056甘氨鹅脱氧胆酸-[d4] (溶液)Glycochenodeoxycholic Acid-[d4] (Solution)[1201918-16-2]
MTCH-10057甘氨鹅脱氧胆酸-[d4]Glycochenodeoxycholic Acid-[d4] [1201918-16-2]
MTCH-10058甘氨鹅脱氧胆酸-[d9] (溶液)Glycochenodeoxycholic Acid-[d9] (Solution)[N/A]
MTCH-10059甘氨鹅脱氧胆酸-[d9]Glycochenodeoxycholic Acid-[d9] [640-79-9]
MTCH-10060甘氨鹅脱氧胆酸钠盐Glycochenodeoxycholic Acid Sodium Salt[16564-43-5]
MTCH-10061甘氨鹅脱氧胆酸钠盐-[d7]Glycochenodeoxycholic Acid-[d7] Sodium Salt (Major)[N/A]
MTCH-10062甘氨鹅脱氧胆酸3-O-β-葡糖苷二钠盐Glycochenodeoxycholic Acid-3-O-Beta(β)-Glucuronide Disodium Salt[75672-22-9]
MTCH-10063甘氨鹅脱氧胆酸3-O-β-葡糖苷二钠盐-[d5] Glycochenodeoxycholic-[d5] Acid-3-O-Beta(β)-Glucuronide Disodium Salt[N/A]
MTCH-10064甘氨鹅脱氧胆酸 3-硫酸二钠盐Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt[66874-09-7]
MTCH-10065甘氨鹅脱氧胆酸 3-硫酸二钠盐-[d5]Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt-[d5][N/A]
MTCH-100667-甲酰氧基甘氨鹅脱氧胆酸乙酯-[d5]7-Formyloxy Glycochenodeoxycholic Acid Ethyl Ester-[d5][N/A]
MTCH-10067表甘氨鹅脱氧胆酸钠盐-[d7]Epi-Glycochenodeoxycholic Acid Sodium Salt-[d7][N/A]
熊胆酸系列


MTCH-10068熊胆酸Ursocholanic Acid[546-18-9]
MTCH-10069甘氨熊胆酸钠盐
[N/A]
MTCH-10070熊脱氧胆酸Ursodeoxycholic Acid[128-13-2]
MTCH-10071熊脱氧胆酸-[d4]Ursodeoxycholic-2,2,4,4-[d4] Acid[347841-46-7]
MTCH-10072熊脱氧胆酸二乙酸甲酯Ursodeoxycholic Acid Diacetate Methyl Ester[N/A]
MTCH-10073熊脱氧胆酸甲酯Ursodeoxycholic Acid Methyl Ester[N/A]
MTCH-100743β-熊脱氧胆酸3Beta(β)-Ursodeoxycholic Acid[78919-26-3]
MTCH-100753β-熊脱氧胆酸-[d4]3Beta(β)-Ursodeoxycholic Acid-[d4][78919-26-3 ( unlabelled)]
MTCH-10076[24-13C]-熊脱氧胆酸[24-13C]-Ursodeoxycholic Acid[63296-46-8]
MTCH-100777- o-乙酰熊脱氧胆酸甲酯7-O-Acetyl Ursodeoxycholic Acid Methyl Ester[75672-24-1]
MTCH-100787- o-乙酰基3β-熊脱氧胆酸甲酯对硝基苯甲酸7-O-Acetyl 3Beta(β)-Ursodeoxycholic Acid Methyl Ester P-Nitrobenzoate[N/A]
货号中文名英文名CAS
MTCH-100793α,7β-二邻乙酰熊脱氧胆酸甲酯3Alpha(α),7Beta(β)-Di-O-Acetyl Ursodeoxycholic Acid Methyl Ester[60384-30-7]
MTCH-100803α,7β-二邻乙酰熊脱氧胆酸甲酯-[d5]3Alpha(α),7Beta(β)-Di-O-Acetyl 24-Nor Ursodeoxycholic Acid-[d5] Methyl Ester[N/A]
MTCH-1008124-脱甲熊脱氧胆酸24-Nor Ursodeoxycholic Acid[99697-24-2]
MTCH-1008224-脱甲熊脱氧胆酸-[d5]24-Nor Ursodeoxycholic Acid-[d5][N/A]
MTCH-1008324-脱甲熊脱氧胆酸甲酯24-Nor Ursodeoxycholic Acid Methyl Ester[118316-16-8]
MTCH-1008424-脱甲熊脱氧胆酸-[d5] 甲酯24-Nor Ursodeoxycholic Acid-[d5] Methyl Ester[N/A]
MTCH-1008524-脱甲熊脱氧胆酸-[d5] (Major)乙酰-Β-D-葡糖苷酸24-Nor Ursodeoxycholic Acid-[d5] (Major) Acyl-Β-D-Glucuronide[N/A]
MTCH-1008624-脱甲熊脱氧胆酸-[d5] (Major) 乙酰-Β-D-葡糖苷酸苄酯24-Nor Ursodeoxycholic Acid-[d5] (Major) Acyl-Β-D-Glucuronide Benzyl Ester[N/A]
MTCH-1008712-酮熊脱氧胆酸12-Ketoursodeoxycholic Acid[81873-91-8]
MTCH-100887-硫代熊脱氧胆酸二钠盐7-Sulfo-Ursodeoxycholic Acid Disodium Salt[191286-16-5]
MTCH-10089甘氨熊脱氧胆酸Glycoursodeoxycholic Acid[64480-66-6]
MTCH-10090甘氨熊脱氧胆酸-[d4] (溶液)Glycoursodeoxycholic Acid-[d4] (Solution)[2044276-17-5]
MTCH-10091甘氨熊脱氧胆酸-[d4]Glycoursodeoxycholic Acid-[d4] [2044276-17-5]
MTCH-10092甘氨熊脱氧胆酸-[d5]Glycoursodeoxycholic Acid-[d5][N/A]
MTCH-10093甘氨熊脱氧胆酸-3-硫酸钠盐Glycoursodeoxycholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10094甘氨熊脱氧胆酸-[d4]-3-硫酸钠盐Glycoursodeoxycholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-10095牛磺熊脱氧胆酸Tauroursodeoxycholic Acid[14605-22-2]
MTCH-10096牛磺熊脱氧胆酸-[d4]钠盐 (溶液)Tauroursodeoxycholic Acid-[d4] Sodium Salt (Solution)[14605-22-2( unlabelled)]
MTCH-10097牛磺熊脱氧胆酸-[d4]钠盐Tauroursodeoxycholic Acid-[d4] Sodium Salt[14605-22-2( unlabelled)]
MTCH-10098牛磺熊脱氧胆酸-[d5]Tauroursodeoxycholic Acid-[d5][1207294-25-4]
MTCH-10099牛磺熊脱氧胆酸-3-硫酸钠盐Tauroursodeoxycholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10100牛磺熊脱氧胆酸-[d4]-3-硫酸钠盐Tauroursodeoxycholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
胆酸系列


MTCH-10186胆酸Cholic Acid[81-25-4]
MTCH-10187胆酸-[d4](溶液)Cholic Acid -[d4] (Solution)[116380-66-6]
MTCH-10188胆酸-[d4]Cholic Acid-[d4][116380-66-6]
MTCH-10189胆酸-[d5]Cholic Acid-[d5][53007-09-3]
MTCH-10190胆酸-[24-13C][24-13C]-Cholic Acid[52886-36-9]
MTCH-10191胆酸-[d4]-3-硫酸钠盐Cholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-101923β-胆酸3Beta(β)-Cholic Acid[3338-16-7]
MTCH-101933β-胆酸-[d5]3Beta(β)-Cholic Acid-[d5][N/A]
MTCH-101943β,5α-胆酸-[d5]3Beta(β),5alpha(α)-Cholic Acid-[d5][N/A]
MTCH-10195牛磺胆酸Taurocholic Acid[81-24-3]
MTCH-10196牛磺胆酸-[d4]Taurocholic Acid-[d4][252030-90-3]
MTCH-10197甘氨胆酸Glycocholic Acid[475-31-0]
MTCH-10198甘氨胆酸-[d4] (溶液)Glycocholic Acid-[d4] (Solution)[1201918-15-1]
MTCH-10199甘氨胆酸-[d4]Glycocholic Acid-[d4][1201918-15-1]
MTCH-10200甘氨胆酸-[d5]Glycocholic Acid-[d5][N/A]
MTCH-10201甘氨胆酸钠盐Glycocholic Acid Sodium Salt[863-57-0]
MTCH-10202甘氨胆酸钠盐Glycocholic Acid Sodium Salt[863-57-0]
MTCH-10203甘氨胆酸水合物Glycocholic Acid Hydrate[1192657-83-2]
货号中文名英文名CAS
MTCH-10204甘氨胆酸水合物钠盐Glycocholic Acid Hydrate Sodium Salt[338950-81-5]
MTCH-10205甘氨胆酸钠盐水合物Glycocholic Acid Sodium Salt Hydrate[207614-05-9]
MTCH-102063β-甘氨胆酸3Beta(β)-Glycocholic Acid[107589-98-0]
MTCH-10207胆酸甲酯3-甲苯磺酸酯Cholic Acid Methyl Ester 3-Tosylate[N/A]
MTCH-10208胆酸甲酯Cholic Acid Methyl Ester[1448-36-8]
脱氧胆酸系列


MTCH-10102脱氧胆酸Deoxycholic Acid[83-44-3]
MTCH-10103脱氧胆酸钠盐Deoxycholic Acid Sodium Salt[N/A]
MTCH-10104脱氧胆酸-[d4]Deoxycholic Acid-[d4][112076-61-6]
MTCH-10105脱氧胆酸-[d4] (溶液)Deoxycholic Acid-[d4] (Solution)[112076-61-6]
MTCH-10106脱氧胆酸-[d5]Deoxycholic Acid-[d5][52840-14-9]
MTCH-10107脱氧胆酸-[d6] (溶液)Deoxycholic Acid-[d6] (Solution)[N/A]
MTCH-10108脱氧胆酸-[d6]Deoxycholic Acid-[d6][N/A]
MTCH-10109[24-13C]-脱氧胆酸[24-13C]-Deoxycholic Acid[52886-37-0]
MTCH-10110脱氧胆酸 3-O-β-D-葡糖苷酸二钠盐Deoxycholic Acid 3-O-Β-D-Glucuronide Disodium Salt[59274-67-8]
MTCH-10111脱氧胆酸 3-O-硫酸二钠盐Deoxycholic Acid 3-O-Sulfate Disodium Salt[60237-35-6]
MTCH-101121β-羟基脱氧胆酸1Beta(β)-Hydroxydeoxycholic Acid[N/A]
MTCH-101131β-羟基脱氧胆酸-[d4](major)1Beta(β)-Hydroxydeoxycholic Acid-[d4](Major)[80434-32-8]
MTCH-101143a,12a-二甲酰氧基脱氧胆酸3Alpha(α),12alpha(α)-Diformyloxydesoxycholic Acid[N/A]
MTCH-10115脱氧胆酸甲酯Deoxycholic Acid Methyl Ester[3245-38-3]
MTCH-10116脱氧胆酸二乙酸酯Deoxycholic Acid Diacetate[N/A]
MTCH-1011712β-脱氧胆酸甲酯3α-苯甲酸酯12Beta(β)-Deoxycholic Acid Methyl Ester 3Α-Benzoate[N/A]
MTCH-1011812α-脱氧胆酸甲酯3α-苯甲酸酯12Alpha(α)-Deoxycholic Acid Methyl Ester 3Α-Benzoate[5969-28-8]
MTCH-10119异脱氧胆酸Isodeoxycholic Acid[566-17-6]
MTCH-101203--脱氧胆酸-[d5]3-Epi-Deoxycholic Acid-[d5][N/A]
MTCH-101213-表脱氧胆酸乙酸甲酯3-Epideoxycholic Acid Acetate Methyl Ester[N/A]
MTCH-10122牛磺脱氧胆酸-[d6]钠盐 (溶液)Taurodeoxycholic Acid-[d6] Sodium Salt (Solution)[N/A]
MTCH-10123牛磺脱氧胆酸-[d6]钠盐Taurodeoxycholic Acid-[d6] Sodium Salt[ unlabelled207737-97-1]
MTCH-10124牛磺脱氧胆酸钠盐水合物Taurodeoxycholic Acid Sodium Salt Hydrate[207737-97-1]
MTCH-10125牛磺脱氧胆酸钠盐Taurodeoxycholic Acid Sodium Salt[1180-95-6]
MTCH-101261β-羟基牛磺脱氧胆酸钠1Beta(β)-Hydroxytaurodeoxycholic Acid Sodium[111945-04-1]
MTCH-101271β-羟基牛磺脱氧胆酸钠-[d4] (major) 1Beta(β)-Hydroxytaurodeoxycholic Acid-[d4] (Major) Sodium[N/A]
MTCH-10128甘氨脱氧胆酸Glycodeoxycholic Acid[360-65-6]
MTCH-10129甘氨脱氧胆酸-[d4] (溶液)Glycodeoxycholic Acid-[d4] (Solution)[1069132-37-1]
MTCH-10130甘氨脱氧胆酸-[d4]Glycodeoxycholic Acid-[d4][1069132-37-1]
MTCH-10131甘氨脱氧胆酸-[d5]Glycodeoxycholic Acid-[d5][N/A]
MTCH-10132甘氨脱氧胆酸-[d6] (溶液)Glycodeoxycholic Acid-[d6] (Solution)[N/A]
MTCH-10133甘氨脱氧胆酸-[d6]Glycodeoxycholic Acid-[d6][N/A]
MTCH-10134甘氨脱氧胆酸钠盐Glycodeoxycholic Acid Sodium Salt[16409-34-0]
MTCH-101351β-羟基牛磺脱氧胆酸-[d4] (major) 钠盐1Beta(β)-Hydroxytaurodeoxycholic Acid-[d4] (Major) Sodium[N/A]
MTCH-101361β-羟基甘氨酸脱氧胆酸1Beta(β)-Hydroxyglycodeoxycholic Acid[N/A]
MTCH-10137甘氨脱氧胆酸-3-O-β-葡萄糖醛酸二钠盐Glycodeoxycholic Acid-3-O-Β-Glucuronide Disodium Salt[75672-36-5]
MTCH-101383-硫代甘氨脱氧胆酸二钠3-Sulfo-Glycodeoxycholic Acid Disodium Salt[66874-10-0]
货号中文名英文名CAS
石胆酸系列


MTCH-10171石胆酸Lithocholic Acid[434-13-9]
MTCH-10172石胆酸-[d4]Lithocholic Acid-[d4][83701-16-0]
MTCH-10173石胆酸-3-硫酸钠盐Lithocholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10174石胆酸-3-硫酸钠盐-[d4]Taurolithocholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-101756-酮基石胆酸6-Ketolithocholic Acid[2393-61-5]
MTCH-101767-酮基石胆酸7-Ketolithocholic Acid[4651-67-6]
MTCH-1017712-酮基石胆酸12-Ketolithocholic Acid[5130-29-0]
MTCH-101786,7-二酮石胆酸6,7-Diketolithocholic Acid[N/A]
MTCH-101797,12-二酮石胆酸7,12-Diketolithocholic Acid[517-33-9]
MTCH-101807,12-二酮石胆酸钠盐7,12-Diketolithocholic Acid Sodium Salt[N/A]
MTCH-10181表别石胆酸Epiallolithocholic Acid[2276-93-9]
MTCH-10182异石胆酸Isolithocholic Acid Acetate[1534-35-6]
MTCH-10183甘氨石胆酸Glycolithocholic Acid[474-74-8]
MTCH-10184甘氨石胆酸-[d4]Glycolithocholic Acid-[d4][2044276-16-4]
MTCH-10185甘氨石胆酸钠盐Glycolithocholic Acid Sodium Salt[24404-83-9]
MTCH-10209甘氨石胆酸-3-硫酸钠盐Glycolithocholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10210甘氨石胆酸-3-硫酸钠盐-[d4]Glycolithocholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-10211牛磺石胆酸Taurolithocholic Acid[516-90-5]
MTCH-10212牛磺石胆酸钠盐Taurolithocholic Acid Sodium Salt[6042-32-6]
MTCH-10213牛磺石胆酸-[d4]钠盐 (溶液)Taurolithocholic Acid-[d4] Sodium Salt (Solution)[N/A]
MTCH-10214牛磺石胆酸-[d4]钠盐Taurolithocholic Acid-[d4] Sodium Salt [N/A]
MTCH-10215牛磺石胆酸-3-硫酸钠盐Taurolithocholic Acid-3-Sulfate Sodium Salt[N/A]
MTCH-10216牛磺石胆酸-3-硫酸钠盐-[d4]Taurolithocholic Acid-[d4]-3-Sulfate Sodium Salt[N/A]
MTCH-1021712-羟基牛磺石胆酸硫酸钠12-Hydroxy Taurolithocholic Acid Sulfate Disodium Salt[66874-07-5]
MTCH-10218磺石胆酸三胺盐Sulfolithocholic Acid Trimethylamine Salt[N/A]
MTCH-102193-硫代甘氨胆酸二钠3-Sulfoglycolithocholic Acid Disodium Salt[64936-82-9]
脱氢胆酸系列


MTCH-10139脱氢胆酸Dehydrocholic Acid[81-23-2]
MTCH-101403-脱氢胆酸 3-Oxodeoxycholic Acid3-Dehydrocholic Acid[2304-89-4]
MTCH-101417-脱氢胆酸 7-Oxodeoxycholic Acid7-Dehydrocholic Acid[911-40-0]
MTCH-1014212-脱氢胆酸12-Dehydrocholic Acid[2458-08-4]
MTCH-101433-脱氢胆酸甲酯3-Dehydrocholic Acid Methyl Ester[N/A]
MTCH-101447-脱氢胆酸甲酯7-Dehydrocholic Acid Methyl Ester[N/A]
MTCH-1014512-脱氢胆酸甲酯12-Dehydrocholic Acid Methyl Ester[N/A]
MTCH-10146脱氢甲酸乙酯Dehydrocholic Acid Ethyl Ester[N/A]
MTCH-101477-脱氢甲酸乙酯7-Dehydrocholic Acid Ethyl Ester[N/A]
MTCH-101487-脱氢胆酸双乙酸酯7-Dehydrocholic Acid Diaceate[N/A]
MTCH-1014912-脱氢胆酸二乙酸酯12-Dehydrocholic Acid Diacetate[N/A]
MTCH-10150甘氨脱氢胆酸Glycodehydrocholic Acid[3415-45-0]
MTCH-10151甘氨脱氢胆酸钠盐Glycodehydrocholic Acid Sodium Salt[N/A]
石胆酸酯系列


MTCH-102206-酮基石胆酸甲酯6-Ketolithocholic Acid Methyl Ester[N/A]
货号中文名英文名CAS
MTCH-102217-酮基石胆酸甲酯7-Ketolithocholic Acid Methyl Ester[N/A]
MTCH-102227,12二酮石胆酸甲酯7, 12-Diketolithocholic Acid Methyl Ester[N/A]
MTCH-10223脱氢石胆酸甲酯Dehydrolithocholic Acid Methyl Ester[N/A]
MTCH-10224石胆酸琥珀酸酯Lithocholic Acid Hemisuccinate[N/A]
MTCH-1022512-酮基石胆酸琥珀酸酯12-Ketolithocholic Acid Hemisuccinate[N/A]
MTCH-10226石胆酸乙酸Lithocholic Acid Acetate[N/A]
MTCH-10227石胆酸乙酸甲酯Lithocholic Acid Acetate Methyl Ester[N/A]
MTCH-102286-酮基石胆酸乙酸甲酯6-Ketolithocholic Acid Acetate Methyl Ester[N/A]
MTCH-102297-酮基石胆酸乙酸甲酯7-Ketolithocholic Acid Acetate Methyl Ester[N/A]
MTCH-102307,12-二酮石胆酸乙酸甲酯7,12-Diketolithocholic Acid Acetate Methyl Ester[N/A]
MTCH-10231异石胆酸乙酸酯Isolithocholic Acid Acetate[N/A]
MTCH-102326-酮石胆酸6-Ketolithocholic Acid[2393-61-5]
MTCH-1023312-酮基石胆酸苯甲酸甲酯12-Ketolithocholic Acid Benzoate, Methyl Ester[17225-41-1]
脱甲胆酸系列


MTCH-1015223-脱甲胆酸二乙酸酯23-Norcholic Acid Diacetate[N/A]
MTCH-1015323-脱甲胆酸23-Norcholic Acid[60696-62-0]
MTCH-10154牛磺-23-脱甲脱氧胆酸钠盐Tauro-23-Nordeoxycholic Acid Sodium Salt[N/A]
MTCH-1015523-脱甲脱氧胆酸甲酯23-Nordeoxycholic Acid Methyl Ester[N/A]
MTCH-1015623-脱甲脱氧胆酸二乙酸酯甲酯23-Nordeoxycholic Acid Diacetate, Methyl Ester[N/A]
MTCH-1015723-脱甲脱氧胆酸二乙酸酯23-Nordeoxycholic Acid Diacetate[N/A]
MTCH-1015823-脱甲脱氧胆酸23-Nordeoxycholic Acid[53608-86-9]
MTCH-10159脱甲脱氧胆酸Nor-Deoxycholic Acid[53608-86-9]
奥贝胆酸系列


MTCH-10160奥贝胆酸Obeticholic Acid[459789-99-2]
MTCH-10161奥贝胆酸-[d4]Obeticholic Acid-[d4][N/A]
MTCH-10162奥贝胆酸-[d5]-钠盐Obeticholic Acid-[d5] Sodium Salt[N/A]
MTCH-10163奥贝胆酸-3-O-β-D-葡糖苷酸Obeticholic Acid 3-O-Beta(β)-D-Glucuronide[2270232-93-2]
MTCH-10164奥贝胆酸酰基-β-D-葡糖苷酸Obeticholic Acid Acyl-Beta(β)-D-Glucuronide[N/A]
MTCH-10165奥贝胆酸酰基-β-D-葡糖苷酸苄酯Obeticholic Acid Acyl-Beta(β)-D-Glucuronide Benzyl Ester[N/A]
MTCH-101666--奥贝胆酸-[d7]6-Epi-Obeticholic Acid-[d7][N/A]
MTCH-10167牛磺奥贝胆酸Tauro-Obeticholic Acid[863239-61-6]
MTCH-10168牛磺奥贝胆酸-[d4]Tauro-Obeticholic Acid-[d4][N/A]
MTCH-10169甘氨奥贝胆酸Glyco Obeticholic Acid[863239-60-5]
MTCH-10170甘氨奥贝胆酸-[d4]Glyco-Obeticholic Acid-[d4][N/A]
其他


MTCH-10240原胆酸Apocholic Acid[641-81-6]
MTCH-10236别胆酸Allocholic Acid[2464-18-8]
MTCH-10234Nutriacholic AcidNutriacholic Acid[4651-67-6]
MTCH-10235Nutriacholic Acid Methyl EsterNutriacholic Acid Methyl Ester[10538-59-7]
MTCH-10237Nor Cholic AcidNor Cholic Acid[60696-62-0]
MTCH-1023812β-羟基异胆酸12Beta(β)-Hydroxyisocholic Acid[71883-64-2]
MTCH-1023912β-羟基异胆酸甲酯12Beta(β)-Hydroxyisocholic Acid Methyl Ester[71883-63-1]


 

 

 

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